Phenotypes Associated with This Genotype

Genotype
MGI:5544263

• Allelic Composition: Septin9^tm2.1Emfu/Septin9^tm2.1Emfu; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:205027 )

• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies

abnormal T cell differentiation ( J:205027 )

• partial at the DN3 to DN4 stage

decreased DN4 thymocyte number ( J:205027 )

increased double-negative T cell number ( J:205027 )

• in the thymus and lymph node

increased DN3 thymocyte number ( J:205027 )

increased CD8-positive, alpha-beta memory T cell number ( J:205027 )

• absolute numbers

decreased T cell number ( J:205027 )

• general reduction in T cells

• more prominent reduction in CD8+ T cells compared with CD4+ T cells

decreased CD4-positive, alpha-beta T cell number ( J:205027 )

• reduced regulatory CD4+ T cells in the spleen

decreased CD4-positive, alpha-beta memory T cell number ( J:205027 )

• absolute numbers

decreased CD8-positive, alpha-beta T cell number ( J:205027 )

• reduced cytotoxic CD8+ T cells in the spleen

decreased CD8-positive, alpha-beta memory T cell number ( J:205027 )

• absolute numbers

decreased regulatory T cell number ( J:205027 )

• reduced regulatory CD4+ T cells in the spleen

• reduced CD3+ T cells

decreased single-positive T cell number ( J:205027 )

• most prominent in young mice

hematopoietic system

decreased T cell proliferation ( J:205027 )

• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies

abnormal T cell differentiation ( J:205027 )

• partial at the DN3 to DN4 stage

increased double-negative T cell number ( J:205027 )

• in the thymus and lymph node

increased DN3 thymocyte number ( J:205027 )

increased CD8-positive, alpha-beta memory T cell number ( J:205027 )

• absolute numbers

decreased T cell number ( J:205027 )

• general reduction in T cells

• more prominent reduction in CD8+ T cells compared with CD4+ T cells

decreased DN4 thymocyte number ( J:205027 )

decreased CD4-positive, alpha-beta T cell number ( J:205027 )

• reduced regulatory CD4+ T cells in the spleen

decreased CD4-positive, alpha-beta memory T cell number ( J:205027 )

• absolute numbers

decreased CD8-positive, alpha-beta T cell number ( J:205027 )

• reduced cytotoxic CD8+ T cells in the spleen

decreased CD8-positive, alpha-beta memory T cell number ( J:205027 )

• absolute numbers

decreased regulatory T cell number ( J:205027 )

• reduced regulatory CD4+ T cells in the spleen

• reduced CD3+ T cells

decreased single-positive T cell number ( J:205027 )

• most prominent in young mice

endocrine/exocrine glands

decreased DN4 thymocyte number ( J:205027 )

increased DN3 thymocyte number ( J:205027 )

cellular

decreased T cell proliferation ( J:205027 )

• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies