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Phenotypes Associated with This Genotype
Genotype
MGI:5544091
Allelic
Composition		 Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Inhibition of vascular development and midgestational lethality in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Edil3Tg(Sox2-cre)1Amc/0 embryos

mortality/aging

cardiovascular system
abnormal vascular development ( J:201133 )
• near complete absence of vascular development at E9.5
enlarged heart ( J:201133 )
• at E9.5-E10.5
internal hemorrhage ( J:201133 )
• pooling of blood in the head and thorax at E9.5-E10.5

embryo
embryonic growth retardation ( J:201133 )
• mild growth retardation at E8.5 and severe retardation at E9.5-E10.5
open neural tube ( J:201133 )
• at E9.5-E10.5

growth/size/body
enlarged heart ( J:201133 )
• at E9.5-E10.5
embryonic growth retardation ( J:201133 )
• mild growth retardation at E8.5 and severe retardation at E9.5-E10.5

nervous system
open neural tube ( J:201133 )
• at E9.5-E10.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory