Analysis Tools
vision/eye
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• some retinal regions are very thin; especially in the ganglion cell and inner nuclear layers or less commonly in the outer nuclear layer
• the peripheral retina is thinner at P6
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• in some regions few or no blood vessels are observed on the vitreal face of the retina while in other regions clusters of blood vessels occupy the vitreal face
• overall density of astrocytes and endothelial cells in the vascularized territory of this retina is several fold higher than in controls
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• many vessels in the developing retinal vascular plexus are not patent at P7 and P11 unlike in controls
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• absence of the normal intraretinal capillary beds in the inner and outer plexiform layers
• absence of vessels in the overlying the peripheral retina at P6
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• some regions are very thin
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• some regions are very thin
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• not as common as in the inner nuclear and ganglion cell layers
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• regions of extensive detachment with numerous macrophages in the subretinal space, severe folding of the retina, accumulation of interstitial fluid, and/or development of interstitial fibrosis
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• interstitial fibrosis is seen in some regions
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retina fold
(
J:201133
)
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• severe folding of the retina
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cardiovascular system
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• in some regions few or no blood vessels are observed on the vitreal face of the retina while in other regions clusters of blood vessels occupy the vitreal face
• overall density of astrocytes and endothelial cells in the vascularized territory of this retina is several fold higher than in controls
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• many vessels in the developing retinal vascular plexus are not patent at P7 and P11 unlike in controls
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• absence of the normal intraretinal capillary beds in the inner and outer plexiform layers
• absence of vessels in the overlying the peripheral retina at P6
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• modest delay in the expansion of the astrocyte front in the developing retina at P3-P6 that is gone by P8
• endothelial cell growth is significantly retarded at all postnatal ages with the radial position of the growing endothelial cells largely arrested by P6
• filopodia-bearing endothelial cells are seen throughout much of the vascular plexus in the retina instead of being located predominantly in the growing front
• large excess of tip cells in the developing retinal vascular plexus
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homeostasis/metabolism
