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Phenotypes Associated with This Genotype
Genotype
MGI:5543677
Allelic
Composition		 Rock1tm1.1Itl/Rock1tm1.1Itl
Tg(Npy-hrGFP)1Lowl/0
Tg(Pomc1-cre)16Lowl/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.1Itl mutation (0 available); any Rock1 mutation (61 available)
Tg(Npy-hrGFP)1Lowl mutation (1 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system electrophysiology ( J:204885 )
• leptin fails to depolarize POMC+ neurons and increase firing rate unlike in control neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory