Phenotypes Associated with This Genotype

Genotype
MGI:5543676

• Allelic Composition: Rock1^tm1.1Itl/Rock1^tm1.1Itl; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

increased epididymal fat pad weight ( J:204885 )

increased mesenteric fat pad weight ( J:204885 )

increased renal fat pad weight ( J:204885 )

• perirenal

homeostasis/metabolism

increased circulating insulin level ( J:204885 )

• at 20 weeks

increased circulating leptin level ( J:204885 )

• at 20 weeks

insulin resistance ( J:204885 )

• modest defect in the ability of insulin to decrease blood glucose

behavior/neurological

increased food intake ( J:204885 )

decreased locomotor activity ( J:204885 )

• during the dark phase

• however, movement during the light phase is normal

growth/size/body

increased body weight ( J:204885 )

skeleton

skeleton phenotype ( J:204885 )

N • mice exhibit normal femur length, bone mineral density and bone mineral content