Phenotypes Associated with This Genotype

Genotype
MGI:5543391

• Allelic Composition: Bub1b^tm1.1Hsl/Bub1b⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spontaneous tumorigenesis in Bub1b^tm1.1Hsl/Bub1b⁺ mice

digestive/alimentary system

increased rectum adenocarcinoma incidence ( J:201641 )

• in 1 of 121 mice

mortality/aging

mortality/aging ( J:201641 )

N • mice are born in Mendelian ratios and do not display premature aging unlike Bub1b^tm2.1Jvd heterozygotes

liver/biliary system

increased hepatocellular carcinoma incidence ( J:201641 )

• in 6 of 121 mice

neoplasm

increased hepatocellular carcinoma incidence ( J:201641 )

• in 6 of 121 mice

increased leukemia incidence ( J:201641 )

• megakaryocytic leukemia in 1 of 121 mice

• metastatic lymphoma/leukemia in 3 of 121 mice

increased lymphoma incidence ( J:201641 )

• metastatic lymphoma/leukemia in 3 of 121 mice

increased B cell derived lymphoma incidence ( J:201641 )

• in 11 of 121 mice

increased adenocarcinoma incidence ( J:201641 )

• in 2 of 121 mice (including 1 mouse with lung adenocarcinoma and 1 mouse with rectal adenocarcinoma)

increased rectum adenocarcinoma incidence ( J:201641 )

• in 1 of 121 mice

increased lung adenocarcinoma incidence ( J:201641 )

• in 1 of 121 mice

increased sarcoma incidence ( J:201641 )

• in 4 of 121 mice (including 2 mice with smooth muscle sarcoma, 1 mouse with endometrial stromal sarcoma and 1 mouse with angiosarcoma)

increased fibrosarcoma incidence ( J:201641 )

• in 1 of 121 mice

increased hemangiosarcoma incidence ( J:201641 )

• in 1 of 121 mice

increased incidence of induced tumors ( J:201641 )

• both solid and hematologic tumors in 46 of 121 mice (including malignant tumors in 28 of 121 mice and benign tumors in 18 of 121 mice)

immune system

increased B cell proliferation ( J:201641 )

• in mice with B cell lymphoma

enlarged spleen ( J:201641 )

increased spleen white pulp amount ( J:201641 )

• in mice with B cell lymphoma

respiratory system

increased lung adenocarcinoma incidence ( J:201641 )

• in 1 of 121 mice

hematopoietic system

increased B cell proliferation ( J:201641 )

• in mice with B cell lymphoma

enlarged spleen ( J:201641 )

increased spleen white pulp amount ( J:201641 )

• in mice with B cell lymphoma

cellular

increased B cell proliferation ( J:201641 )

• in mice with B cell lymphoma

growth/size/body

enlarged spleen ( J:201641 )