Phenotypes Associated with This Genotype

Genotype
MGI:5543251

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mismatch repair ( J:204653 )

• DNA mismatch repair (measured by cre reversion and activation of the lacZ reporter) is increased about 100 fold relative to mice heterozygous form the Pms2 allele

• average numbers of gastrointestinal tract spots (stained villi) in homozygous Pms2 mutants is 3300 compared to 26 in Pms2 heterozygotes

homeostasis/metabolism

abnormal mismatch repair ( J:204653 )

• DNA mismatch repair (measured by cre reversion and activation of the lacZ reporter) is increased about 100 fold relative to mice heterozygous form the Pms2 allele

• average numbers of gastrointestinal tract spots (stained villi) in homozygous Pms2 mutants is 3300 compared to 26 in Pms2 heterozygotes