Phenotypes for Oprm1 MGI:5538574 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Oprm1^tm1Kff/Oprm1^tm1Kff
Genetic Background	involves: 129S2/SvPas * C57BL/6J

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Kff mutation (1 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal social investigation ( J:204731 )

• males do not show a change in social exploratory activity when exposed to playback of female ultrasonic vocalizations unlike wild-type males that exhibit an increase of exploratory activity

• males however, exhibit normal behavior in the auditory cued-fear conditioning task

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:204731

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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