Mouse Genome Informatics
cx
    Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Fgf9,-EGFP)#Dor/0

involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• 2 of 5 mutants that develop ascites after 4 months of doxycycline induction contain cells with malignant cytology
• one day following doxycycline administration, adult mutants exhibit formation of small nodules (epithelial clusters) on the lung surface
• one day following doxycycline administration, adult mutants exhibit formation of small nodules (epithelial clusters) on the lung surface
• papillary adenoma and papillary adenocarcinoma develop in mice treated with doxycycline for 4 and 8 days, respectively
• small tumor nodules and large tumor nodules persist in the lungs of mutants treated with doxycycline for 2-4 days followed by 1 month of doxycycline and in mutants treated with doxycycline for 2 weeks followed by 9 and 18 weeks of withdrawal, respectively
• after 4 days of doxycycline induction, nodules are histologically consistent with papillary adenoma
• after 8 days of doxycycline induction, the cells forming papillary structures become atypical with larger and hyperchromatic nuclei, consistent with papillary adenocarcinoma

mortality/aging
• doxycycline treated adults show a median survival of 89 days and die due to respiratory failure

respiratory system
• doxycycline treated adults die due to respiratory failure

homeostasis/metabolism
• mutants surviving 4 months of doxycycline induction develop ascites

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:204282