Phenotypes Associated with This Genotype

Genotype
MGI:5532835

• Allelic Composition: Mapk14^tm1.2Otsu/Mapk14^tm1.2Otsu; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

short femur ( J:204227 )

♂ • at 6 months in male mice

short tibia ( J:204227 )

♂ • at 6 months in male mice

abnormal long bone epiphyseal plate proliferative zone ( J:204227 )

♂ • narrow in male mice

decreased width of hypertrophic chondrocyte zone ( J:204227 )

♂ • in male mice

decreased long bone epiphyseal plate size ( J:204227 )

♂ • in male mice

kyphosis ( J:204227 )

♂ • exaggerated in male mice at 6 months

small vertebrae ( J:204227 )

♂ • short at 6 months in male mice

growth/size/body

decreased body size ( J:204227 )

• by 3 to 4 weeks in female and male mice

decreased body length ( J:204227 )

• in male and female mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:204227 )

N • mice exhibit normal IGF1 serum levels

limbs/digits/tail

short femur ( J:204227 )

♂ • at 6 months in male mice

short tibia ( J:204227 )

♂ • at 6 months in male mice