Phenotypes for Ampd3 Pklr MGI:5529923 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ampd3^tm1Tm/Ampd3^tm1Tm Pklr^slc/Pklr^slc
Genetic Background	involves: CBA/NSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ampd3^tm1Tm mutation (0 available); any Ampd3 mutation (39 available)
Pklr^slc mutation (0 available); any Pklr mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged spleen ( J:203909 )

hematopoietic system

enlarged spleen ( J:203909 )

anemia ( J:203909 )

abnormal erythrocyte morphology ( J:203909 )

reticulocytosis ( J:203909 )

abnormal erythrocyte physiology ( J:203909 )

• ATP, ADP, and AMP levels increase in RBC

increased erythrocyte osmotic fragility ( J:203909 )

• RBC are more fragile under low osmotic conditions

immune system

enlarged spleen ( J:203909 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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