Phenotypes Associated with This Genotype

Genotype
MGI:5529919

• Allelic Composition: Ampd3^tm1Tm/Ampd3^tm1Tm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased mean corpuscular volume ( J:203909 )

• slight but significant increase

abnormal erythrocyte physiology ( J:203909 )

• ATP, ADP, and AMP levels increase in RBC

• ATP, ADP, and AMP levels drop with fasting but remain higher than for controls

• GTP levels decrease

increased erythrocyte osmotic fragility ( J:203909 )

• RBC are more fragile under low osmotic conditions

• RBC fragility is unaffected by fasting

immune system

lung inflammation ( J:201211 )

• greatly increased inflammation relative to controls in lungs after hind-limb ischemia and reperfusion

respiratory system

lung inflammation ( J:201211 )

• greatly increased inflammation relative to controls in lungs after hind-limb ischemia and reperfusion