Phenotypes Associated with This Genotype

Genotype
MGI:5529819

• Allelic Composition: Hba^tm1Paz/Hba^tm1Paz; Hbb^tm1Tow/Hbb^tm1Tow
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:204029 )

• fewer than expected mice are present at E12.5

• no viable mice are present at E11.5

• mice die between E10.5 and E12.5

hematopoietic system

microcytic anemia ( J:204029 )

• extreme at E12.5, indicated by pallor and small fetal liver

abnormal erythroid progenitor cell morphology ( J:204029 )

• a small population of Ter119+ CD71^low fetal liver cells unlike in wild-type mice

decreased erythroid progenitor cell number ( J:204029 )

• Ter119+ CD71^hi

microcytosis ( J:204029 )

• primitive erythroblasts at E11.5

abnormal embryonic erythrocyte morphology ( J:204029 )

• increased nuclear to cytoplasmic ratio, less condensed and granular nucleus and smaller, less basophilic staining cytoplasm

abnormal embryonic erythropoiesis ( J:204029 )

• severely impaired at E12.5

• mice exhibit a block in differentiation at the proerythroblast/basophilic erythroblast stage in fetal liver erythropoiesis compared with wild-type mice

liver/biliary system

small liver ( J:204029 )

• at E12.5

liver hypoplasia ( J:204029 )

• fetal liver

embryo

decreased embryo size ( J:204029 )

• slightly at E12.5

abnormal embryonic erythropoiesis ( J:204029 )

• severely impaired at E12.5

• mice exhibit a block in differentiation at the proerythroblast/basophilic erythroblast stage in fetal liver erythropoiesis compared with wild-type mice

growth/size/body

decreased embryo size ( J:204029 )

• slightly at E12.5

integument

pallor ( J:204029 )

• at E12.5