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Phenotypes Associated with This Genotype
Genotype
MGI:5529794
Allelic
Composition
Tg(Thy1-MAPT*)1Avil/Tg(Thy1-MAPT*)1Avil
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 10-30% of mice show epileptic seizures at all ages analyzed
• mice show increased sensitivity to the chemoconvulsant agent pentylenetetrazol, showing reduced seizure latency, increased seizure length and increased lethality compared to controls
• 70% of mutants exhibit spontaneous myoclonus at 5.5 months of age
• mutants display myoclonic jerks and periods of immobility followed by a seizure
• 10% of mutants exhibit spontaneous generalized tonic-clonic seizures (generalized low-frequency polyspike-wave discharges) at 14 months of age
• mutants show nonconvulsive spontaneous seizures with EEG correlates corresponding to epileptic rhythmic, spindle-shaped discharges
• phosphorylated-tau aggregates are seen in the brain
• reactive gliosis in the hippocampus
• activated microglia in the brain
• reactive astrocytes in the brain

behavior/neurological
• 10-30% of mice show epileptic seizures at all ages analyzed
• mice show increased sensitivity to the chemoconvulsant agent pentylenetetrazol, showing reduced seizure latency, increased seizure length and increased lethality compared to controls
• 70% of mutants exhibit spontaneous myoclonus at 5.5 months of age
• mutants display myoclonic jerks and periods of immobility followed by a seizure
• 10% of mutants exhibit spontaneous generalized tonic-clonic seizures (generalized low-frequency polyspike-wave discharges) at 14 months of age
• mutants show nonconvulsive spontaneous seizures with EEG correlates corresponding to epileptic rhythmic, spindle-shaped discharges

hematopoietic system
• activated microglia in the brain

immune system
• activated microglia in the brain

muscle
• 70% of mutants exhibit spontaneous myoclonus at 5.5 months of age
• mutants display myoclonic jerks and periods of immobility followed by a seizure

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
J:201700


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory