Phenotypes for Itgb1 Tg(KRT5-cre)5132Jlj MGI:5529164 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Itgb1^tm1Ref/Itgb1^tm14.1Ref Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1^tm14.1Ref mutation (0 available); any Itgb1 mutation (58 available)
Itgb1^tm1Ref mutation (0 available); any Itgb1 mutation (58 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:203018 )

N	• mice exhibit normal follicle morphogenesis and keratinocyte spreading and proliferation

decreased keratinocyte migration ( J:203018 )

abnormal hair growth ( J:203018 )

• patchy hair loss over the dorsal midline of the skull

abnormal epidermal layer morphology ( J:203018 )

• less affected than in Itgb1^tm1Ref/Itgb1^tm1Ref Tg(KRT1-5-cre)5132Jlj mice

• however, no subepidermal blistering is observed

homeostasis/metabolism

delayed wound healing ( J:203018 )

• in a scratch wounding assay

cellular

decreased keratinocyte migration ( J:203018 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24