Phenotypes Associated with This Genotype

Genotype
MGI:5529163

• Allelic Composition: Itgb1^tm1Ref/Itgb1^tm15.1Ref; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased keratinocyte adhesion ( J:203018 )

• defective adhesion and more pronounced spreading

decreased keratinocyte proliferation ( J:203018 )

• cells do not grow into a confluent monolayer and undergo rapidly initiated terminal differentiation

abnormal hair growth ( J:203018 )

• patchy hair loss over the dorsal midline of the skull

enlarged hair follicles ( J:203018 )

• intermixed with normal follicles

abnormal epidermal layer morphology ( J:203018 )

• less affected than in Itgb1^tm1Ref/Itgb1^tm1Ref Tg(KRT1-5-cre)5132Jlj mice

• however, no subepidermal blistering is observed

cellular

decreased keratinocyte adhesion ( J:203018 )

• defective adhesion and more pronounced spreading

decreased keratinocyte proliferation ( J:203018 )

• cells do not grow into a confluent monolayer and undergo rapidly initiated terminal differentiation