Phenotypes Associated with This Genotype

Genotype
MGI:5529143

• Allelic Composition: Atoh7^{tm1.1(Ascl1)Nlbr}/Atoh7^{tm1.1(Ascl1)Nlbr}; Tg(Atoh7-cre)360Gla/0; Tg(CAG-Bgeo/GFP)21Lbe/0
• Genetic Background: either: (involves: 129 * C57BL/6 * FVB/N * SJL) or (involves: 129 * C57BL/6 * CD-1 * FVB/N * SJL)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:203642 )

• increased retinal apoptosis at E12.5 to E16.5

decreased retina ganglion cell number ( J:203642 )

• cell autonomous phenotype

increased retina cone cell number ( J:203642 )

• cell nonautonomous phenotype

abnormal retina progenitor cell morphology ( J:203642 )

• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression and retinal ganglion cell differentiation

nervous system

decreased retina ganglion cell number ( J:203642 )

• cell autonomous phenotype

increased retina cone cell number ( J:203642 )

• cell nonautonomous phenotype

cellular

abnormal cell cycle ( J:203642 )

• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression

increased retina apoptosis ( J:203642 )

• increased retinal apoptosis at E12.5 to E16.5