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Phenotypes Associated with This Genotype
Genotype
MGI:5529020
Allelic
Composition		 Mirc14tm1.2Flv/Mirc14tm1.2Flv
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.2Flv mutation (0 available); any Mirc14 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:203157 )
• in bone marrow chimeras reconstitution experiments whether reconstituted with Mirc14-deficient or wild-type bone marrow
abnormal T cell receptor V(D)J recombination ( J:203157 )
• Jalpha gene usage is biased in favor of proximal versus distal segments
decreased double-positive T cell number ( J:203157 )
• in dexmethasone-treated mice
decreased B cell number ( J:203157 )
• in the bone marrow
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal T cell physiology ( J:203157 )
• thymocytes exhibit reduced extracellular acidification rate indicating decreased glycolysis compared with wild-type cells
• however, thymocytes exhibit normal oxygen consumption, mitochondrial mass, and mitochondrial reactive oxygen species production
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

cellular
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

hematopoietic system
abnormal T cell differentiation ( J:203157 )
• in bone marrow chimeras reconstitution experiments whether reconstituted with Mirc14-deficient or wild-type bone marrow
abnormal T cell receptor V(D)J recombination ( J:203157 )
• Jalpha gene usage is biased in favor of proximal versus distal segments
decreased double-positive T cell number ( J:203157 )
• in dexmethasone-treated mice
decreased B cell number ( J:203157 )
• in the bone marrow
decreased NK T cell number ( J:203157 )
• in the thymus, spleen and liver of mice treated with alpha- galactosylceramide CD1d1 tetramer
abnormal T cell physiology ( J:203157 )
• thymocytes exhibit reduced extracellular acidification rate indicating decreased glycolysis compared with wild-type cells
• however, thymocytes exhibit normal oxygen consumption, mitochondrial mass, and mitochondrial reactive oxygen species production
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice
decreased T cell proliferation ( J:203157 )
• of double positive thymocytes

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:203157 )
• in thymocytes cultured with dexamethasone
• in dexamethasone-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory