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Phenotypes Associated with This Genotype
involves: 129S6/SvEvTac * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrbtm1.1Syc mutation (0 available); any Thrb mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• males, but not females, habituate less after multiple sessions of exploratory locomotor activity
• females require more sessions to reach criterion of greater than 80% hits on three consecutive sessions of the vigilance task, indicating impaired leaning on a task that requires sustained attention
• females exhibit faster reaction times under baseline conditions during the vigilance task
• male vigilance is unaffected by treatment with the psychostimulant methylphenidate unlike in wild-type mice or mutant females which show impaired vigilance performance in response to methylphenidate
• females rear less than wild-type females
• males, but not females, exhibit hyperactivity after multiple sessions of exploratory locomotor activity (after habituation)
• males exhibit a faster rate of acquisition of a nose-poke response on the response acquisition task, however, they also respond more than wild-type mice in the inactive nose-poke hole, indicating a greater baseline response rate inside the operant-conditioning chambers and males show a decrease in inactive response rate after multiple session and perform similarly to controls, suggesting that differences in acquisition are due to increased activity and not to improved learning
• during the first 3 sessions of response acquisition, females show a greater rate of responding in the inactive nose-poke holes than wild-type females but do not differ in the rate of change over multiple sessions, suggesting hyperactivity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory