Mouse Genome Informatics
involves: 129S6/SvEvTac * NIH Black Swiss
phenotype observed in females
phenotype observed in males
N normal phenotype
• males, but not females, habituate less after multiple sessions of exploratory locomotor activity
• females require more sessions to reach criterion of greater than 80% hits on three consecutive sessions of the vigilance task, indicating impaired leaning on a task that requires sustained attention
• females exhibit faster reaction times under baseline conditions during the vigilance task
• male vigilance is unaffected by treatment with the psychostimulant methylphenidate unlike in wild-type mice or mutant females which show impaired vigilance performance in response to methylphenidate
• females rear less than wild-type females
• males, but not females, exhibit hyperactivity after multiple sessions of exploratory locomotor activity (after habituation)
• males exhibit a faster rate of acquisition of a nose-poke response on the response acquisition task, however, they also respond more than wild-type mice in the inactive nose-poke hole, indicating a greater baseline response rate inside the operant-conditioning chambers and males show a decrease in inactive response rate after multiple session and perform similarly to controls, suggesting that differences in acquisition are due to increased activity and not to improved learning
• during the first 3 sessions of response acquisition, females show a greater rate of responding in the inactive nose-poke holes than wild-type females but do not differ in the rate of change over multiple sessions, suggesting hyperactivity

Mouse Models of Human Disease
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:114325
Thyroid Hormone Resistance, Generalized, Autosomal Dominant; GRTH 188570 J:114325