Phenotypes Associated with This Genotype

Genotype
MGI:5528857

• Allelic Composition: Ank1^M1Btlr/Ank1^M1Btlr
• Genetic Background: C57BL/6J-Ank1^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:203831 )

• slightly

hematopoietic system

extramedullary hematopoiesis ( J:203831 )

• in the spleen

abnormal erythrocyte morphology ( J:203831 )

• membrane blebs

increased erythrocyte cell number ( J:203831 )

decreased mean corpuscular hemoglobin ( J:203831 )

decreased mean corpuscular volume ( J:203831 )

microcytosis ( J:203831 )

spherocytosis ( J:203831 )

stomatocytosis ( J:203831 )

reticulocytosis ( J:203831 )

• mild

abnormal spleen morphology ( J:203831 )

• effacement of normal spleen architecture

enlarged spleen ( J:203831 )

• slightly

increased spleen iron level ( J:203831 )

hemolysis ( J:203831 )

• erythrocyte half-life is 18 days compared with 28 in wild-type mice

increased erythrocyte osmotic fragility ( J:203831 )

• increased osmotic fragility

homeostasis/metabolism

increased spleen iron level ( J:203831 )

increased circulating bilirubin level ( J:203831 )

increased circulating erythropoietin level ( J:203831 )

• at 8 weeks

immune system

abnormal spleen morphology ( J:203831 )

• effacement of normal spleen architecture

enlarged spleen ( J:203831 )

• slightly

increased spleen iron level ( J:203831 )