Phenotypes Associated with This Genotype

Genotype
MGI:5527441

• Allelic Composition: Degs1^{Gt(OST368559)Lex}/Degs1^{Gt(OST368559)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:203554 )

• mice die between 8 and 10 weeks

preweaning lethality, incomplete penetrance ( J:203554 )

• fewer than expected mice are observed among the offspring of heterozygous mice

homeostasis/metabolism

abnormal homeostasis ( J:203554 )

increased circulating bilirubin level ( J:203554 )

increased circulating alanine transaminase level ( J:203554 )

increased circulating alkaline phosphatase level ( J:203554 )

abnormal ceramide level ( J:203554 )

• reduced ceramide with more dihydroceramide in pups

• lack of ceramide in the heart, liver, pancreas, white adipose tissue and soleus muscle from 7 weeks

growth/size/body

decreased lean body mass ( J:203554 )

decreased body size ( J:203554 )

decreased body weight ( J:203554 )

decreased body length ( J:203554 )

postnatal growth retardation ( J:203554 )

skeleton

decreased bone mineral content ( J:203554 )

decreased bone mineral density ( J:203554 )

integument

sparse hair ( J:203554 )

scaly skin ( J:203554 )

behavior/neurological

tremors ( J:203554 )

hematopoietic system

abnormal hematopoietic system morphology/development ( J:203554 )

• numerous hematological abnormalities

liver/biliary system

decreased liver function ( J:203554 )