About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5527328
Allelic
Composition		 Cyfip2M1N/Cyfip2M1N
Genetic
Background		 C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2M1N mutation (1 available); any Cyfip2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:203183 )
• fewer total spines and spines of each class compared with C57BL/6J mice
decreased miniature excitatory postsynaptic current frequency ( J:203183 )
• decreased miniature excitatory postsynaptic current frequency compared with C57BL/6J mice
• however, amplitude is normal

behavior/neurological
impaired behavioral response to cocaine ( J:203183 )
• compared with C57BL/6J mice
• however, cocaine metabolism is the same as in C57BL/6J mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory