Phenotypes Associated with This Genotype

Genotype
MGI:5527290

• Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn; Park7^tm1Shn/Park7^tm1Shn
• Genetic Background: B6.Cg-Park7^tm1Shn Prkn^tm1Shn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:202221 )

• increased latency to fall (rotarod test) observed at 6, 12, 13, 16 and 18 months of age as compared to controls

• trained mutant mice remain on rotarod longer than trained wild type at all speeds tested (5, 10, 15 and 20 rpm) and spend less time "distracted" while on the rod

homeostasis/metabolism

increased serotonin level ( J:202221 )

• striatal serotonin levels are increased at 12 and 18 months of age

• hippocampal serotonin levels are increased in 15 months old mice