Phenotypes for Gpx1 Park7 Prkn MGI:5527284 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gpx1^tm1Ysh/Gpx1^tm1Ysh Prkn^tm1Shn/Prkn^tm1Shn Park7^tm1Shn/Park7^tm1Shn
Genetic Background	B6.Cg-Park7^tm1Shn Gpx1^tm1Ysh Prkn^tm1Shn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1^tm1Ysh mutation (2 available); any Gpx1 mutation (24 available)
Park7^tm1Shn mutation (2 available); any Park7 mutation (56 available)
Prkn^tm1Shn mutation (3 available); any Prkn mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:202221 )

• increased latency to fall (rotarod test) observed at 12 and 18 months of age as compared to controls

homeostasis/metabolism

increased dopamine level ( J:202221 )

• striatal dopamine levels are significantly elevated at 6, 12 and 18 months of age, however, dopamine turnover is similar to controls

increased serotonin level ( J:202221 )

• striatal serotonin levels are increased at 12 months of age, however, serotonin turnover is similar to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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