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Phenotypes Associated with This Genotype
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm5.1Gpr mutation (2 available); any Tecta mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• reduced hair-bundle attachment with imprints only apparent in apical, lower-frequency regions
• Hensen's stripe is no longer attached directly to the tectorial membrane
• hump-backed tectorial membrane with reduced extent of the limbal zone and medially displaced marginal band
• most apparent changes are in the cross-sectional profile and the extent of limbal attachment
• the dense matrix is mostly missing from the severely reduced limbal zone
• collagen fibrils erupt form the upper surface of the tectorial membrane in the inner sulcal region and occasionally extend out from the lower surface in the sulcal region immediately adjacent to the limbal attachment point
• Kimura's membrane is delaminated and fenestrated
• covernet fibrils are reduced in numbers, more convoluted and run both longitudinally and radially across the surface of the tectorial membrane compared to in wild-type mice
• covernet fibrils in the sulcal and more medial regions are less tightly associated with the main body of the tectorial membrane
• the striated-sheet matrix is restricted to the lateral part of the tectorial membrane
• more severe hearing loss than in Tectatm3.1Gpr or Tectatm4.1Gpr heterozygotes
• however, increase is stable with time

• preceded by wild running

nervous system
• preceded by wild running
• reduced hair-bundle attachment with imprints only apparent in apical, lower-frequency regions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant nonsyndromic deafness 12 DOID:0110544 OMIM:601543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory