Mouse Genome Informatics
ht
    Tectatm3.1Gpr/Tecta+
involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hearing/vestibular/ear
• reduced hair-bundle attachment with imprints not observed in the apical, low-frequency regions and are only apparent in more basal regions
• distorted cross-sectional profile with the limbal zone that does not extend fully across the surface of the spiral limbus in the medial direction, disrupted marginal band and not as prominent Hensen's stripe as in wild-type mice
• the covernet is hard to discern with reduced fibril diameter with the presence of exceptionally large diameter fibrils
• Hensen's stripe lack typical V-shape
• less severe hearing loss than in Tectatm4.1Gpr or Tectatm5.1Gpr heterozygotes
• however, increase is stable with time
• less severe hearing loss than in Tectatm4.1Gpr or Tectatm5.1Gpr heterozygotes

behavior/neurological
• preceded by wild running

nervous system
• preceded by wild running
• reduced hair-bundle attachment with imprints not observed in the apical, low-frequency regions and are only apparent in more basal regions

Mouse Models of Human Disease
OMIM IDRef(s)
Deafness, Autosomal Dominant 12; DFNA12 601543 J:203482