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Phenotypes Associated with This Genotype
Genotype
MGI:5527171
Allelic
Composition
Tectatm3.1Gpr/Tecta+
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm3.1Gpr mutation (1 available); any Tecta mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• reduced hair-bundle attachment with imprints not observed in the apical, low-frequency regions and are only apparent in more basal regions
• Hensen's stripe not as prominent as in wild-type mice
• Hensen's stripe lacks typical V-shape
• distorted cross-sectional profile with the limbal zone not extending fully across the surface of the spiral limbus in the medial direction, disrupted marginal band, and not as prominent Hensen's stripe as in wild-type mice
• the covernet is hard to discern with reduced fibril diameter with the presence of exceptionally large diameter fibrils
• less severe hearing loss than in Tectatm4.1Gpr or Tectatm5.1Gpr heterozygotes
• however, increase is stable with time
• less severe hearing loss than in Tectatm4.1Gpr or Tectatm5.1Gpr heterozygotes

behavior/neurological
• preceded by wild running

nervous system
• preceded by wild running
• reduced hair-bundle attachment with imprints not observed in the apical, low-frequency regions and are only apparent in more basal regions

Mouse Models of Human Disease
OMIM ID Ref(s)
Deafness, Autosomal Dominant 12; DFNA12 601543 J:203482


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory