Phenotypes Associated with This Genotype

Genotype
MGI:5527081

• Allelic Composition: Stip1^tm1.2Mamp/Stip1⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:201097 )

• following middle cerebral artery occlusion

nervous system

abnormal astrocyte physiology ( J:201097 )

• increased double-strand breaks in astrocytes

• however, astrocytes exhibit normal proliferation and response to oxygen and glucose deprivation

increased susceptibility to ischemic brain injury ( J:201097 )

• however, the mice that survive stroke injury recover normally

• following middle cerebral artery occlusion, mice exhibit increased mortality, infarct volume and decreased dexterity to removing tape on their ipsilateral ischemic side compared with wild-type mice

increased cerebral infarct size ( J:201097 )

• following middle cerebral artery occlusion

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in astrocytes

increased susceptibility to ischemic brain injury ( J:201097 )

• following middle cerebral artery occlusion, mice exhibit increased mortality, infarct volume and decreased dexterity to removing tape on their ipsilateral ischemic side compared with wild-type mice

• however, the mice that survive stroke injury recover normally

increased cerebral infarct size ( J:201097 )

• following middle cerebral artery occlusion

cellular

abnormal astrocyte physiology ( J:201097 )

• increased double-strand breaks in astrocytes

• however, astrocytes exhibit normal proliferation and response to oxygen and glucose deprivation

abnormal double-strand DNA break repair ( J:201097 )

• increased double-strand breaks in astrocytes