Mouse Genome Informatics
ht
    CrxRip/Crx+
C57BL/6J-CrxRip
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• small with poor blood flow
• long term preservation of immature cone-like photoreceptors
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
• very short
• however, ciliary microtubules are detected
• however, ciliary microtubules are detected
N
• the outer nuclear layer thickness is preserved up to 18 months (J:203337)
• white spots
• complete absence of cone visual response at 1 month
• complete absence of rod visual response at 1 month
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter

cardiovascular system
• small with poor blood flow
• poor blood flow in retinal blood vessels

nervous system
• long term preservation of immature cone-like photoreceptors
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
• very short
• however, ciliary microtubules are detected
• however, ciliary microtubules are detected

Mouse Models of Human Disease
OMIM IDRef(s)
Leber Congenital Amaurosis 7; LCA7 613829 J:203337