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Phenotypes Associated with This Genotype
Genotype
MGI:5526862
Allelic
Composition
CrxRip/Crx+
Genetic
Background
C57BL/6J-CrxRip
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrxRip mutation (0 available); any Crx mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

CrxRip/Crx+ retinal photoreceptors lack outer segments and possess very short inner segments

vision/eye
• small with poor blood flow
• long term preservation of immature cone-like photoreceptors
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
• very short
• however, ciliary microtubules are detected
• however, ciliary microtubules are detected
N
• the outer nuclear layer thickness is preserved up to 18 months
• white spots
• complete absence of cone visual response at 1 month
• complete absence of rod visual response at 1 month
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter

cardiovascular system
• small with poor blood flow
• poor blood flow in retinal blood vessels

nervous system
• long term preservation of immature cone-like photoreceptors
• however, rod phenotype is partially rescued by transgenic expression of Nrl under the control of the Crx promoter
• very short
• however, ciliary microtubules are detected
• however, ciliary microtubules are detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Leber Congenital Amaurosis 7; LCA7 613829 J:203337


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory