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Phenotypes Associated with This Genotype
Genotype
MGI:5525147
Allelic
Composition
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Epas1tm1Mcs/Epas1tm1Mcs
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Epas1tm1Mcs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (23 available)
Epas1tm1Mcs mutation (1 available); any Epas1 mutation (66 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (3 available); any Gt(ROSA)26Sor mutation (1098 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• hematocrit level, erythropoietin level and spleen architecture and weight are similar to mice without cre/ESR1 allele
• the Epas1 allele functions to rescue the erythrocytosis phenotype

mortality/aging
• survival is improved relative to mice carrying the Egln1 null allele, but not to control levels


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory