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Phenotypes Associated with This Genotype
Genotype
MGI:5525145
Allelic
Composition		 Slc12a3tm1Ges/Slc12a3tm1Ges
Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a3tm1Ges mutation (1 available); any Slc12a3 mutation (53 available)
Tg(Wnk4*Q562E)#Rpl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:113094 )
N
• on both normal and high-potassium diets, mice show reduced blood pressure levels compared to single Tg(Wnk4*Q562E)#Rpl homozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:113094 )
N
• on both normal and high-potassium diets, mice show normal serum potassium and calcium levels

renal/urinary system
renal/urinary system phenotype ( J:113094 )
N
• on both normal and high-potassium diets, mice show elimination of distal convoluted tube hyperplasia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory