Phenotypes Associated with This Genotype

Genotype
MGI:5524259

• Allelic Composition: Bace1^tm1Psa/Bace1^tm1Psa
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle spindle morphology ( J:199150 )

• small diameter and few intrafusal fibers

decreased muscle spindle number ( J:199150 )

• in newborn mice persisting through adulthood

• however, muscle spindle number at P0 is normal

behavior/neurological

impaired coordination ( J:199150 )

• mice hang on to an inverted grid 3 times less than wild-type mice

abnormal gait ( J:199150 )

• impaired left/right coordination

• swaying walking

nervous system

abnormal muscle spindle morphology ( J:199150 )

• small diameter and few intrafusal fibers

decreased muscle spindle number ( J:199150 )

• in newborn mice persisting through adulthood

• however, muscle spindle number at P0 is normal

demyelination ( J:199150 )

• peripheral without Schwann cell turn-over