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Phenotypes Associated with This Genotype
Genotype
MGI:5524258
Allelic
Composition		 Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation (0 available); any Bace1 mutation (30 available)
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
decreased muscle spindle number ( J:199150 )
• more pronounced in Nrg1tm4.1Cbm homozygotes

nervous system
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
decreased muscle spindle number ( J:199150 )
• more pronounced in Nrg1tm4.1Cbm homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory