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Phenotypes Associated with This Genotype
Genotype
MGI:5524086
Allelic
Composition
Tg(MMTV-Myc*T58A)TA14Jrn/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mutants develop mammary tumors (J:153233)
• less than 10% of tumors are microacinar (J:153233)
• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)
• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition type (EMT), solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)
• Kras activating mutations are seen in 14.6% of tumors (J:193362)
• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)
• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

endocrine/exocrine glands
• mammary glands show increased side bud formation at 8 weeks of age
• mutants develop mammary tumors (J:153233)
• less than 10% of tumors are microacinar (J:153233)
• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)
• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition type (EMT), solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)
• Kras activating mutations are seen in 14.6% of tumors (J:193362)
• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)
• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

integument
• mammary glands show increased side bud formation at 8 weeks of age
• mutants develop mammary tumors (J:153233)
• less than 10% of tumors are microacinar (J:153233)
• 40% of tumors exhibit a papillary histology, characterized by fibrovascular stalks lined by columnar cells that extend into gland-like spaces (J:153233)
• the remainder of tumors show various other morphologies including, squamous, epithelial-mesenchymal-transition type (EMT), solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)
• Kras activating mutations are seen in 14.6% of tumors (J:193362)
• mice with tumors containing a Kras mutation show a similar latency compared to mice with tumors without a mutation (J:193362)
• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:193362


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory