Phenotypes Associated with This Genotype

Genotype
MGI:5524044

• Allelic Composition: Nhlh2^tm1Thbr/Nhlh2^tm1Thbr; Tg(Pomc-EGFP)1Low/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuron number ( J:199640 )

• Pomc+ neurons at 15 to 21 weeks in the medial preoptic area and posterior hypothalamus

increased neuron number ( J:199640 )

♀ • Pomc+ neurons in female mice at 3 and 6 weeks in the medial preoptic area, posterior hypothalamus and arcuate nuclei of the hypothalamus with ectopic neurons in the medial mammillary nucleus

♀ • however, the numbers decline after 9 weeks with the onset of puberty

ectopic neuron ( J:199640 )

♀ • ectopic Pomc+ neurons in female mice at 3 and 6 weeks in the medial mammillary nucleus