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Phenotypes Associated with This Genotype
Genotype
MGI:5523906
Allelic
Composition
Cntn1usl/Cntn1usl
Genetic
Background
MRL/MpJ-Faslpr Cntn1usl/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn1usl mutation (1 available); any Cntn1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lower than expected Mendelian ratio of homozygotes from heterozygous intercross indicates embryonic or perinatal lethality
• all homozygotes die by 3 weeks of age

growth/size/body
• runted body size and lack of vitality

behavior/neurological
• homozygotes splay their hind legs, stagger from side-to-side, and a few may lean their head to the side or circle slowly
• hind limbs can be splayed

nervous system
• a few apoptotic granule cells were found in the cerebellum of one of two homozygous females assessed at 2 weeks of age
• marked gliosis of the white matter of the spinal cord was found in a homozygous female at 2 weeks of age

digestive/alimentary system
• hyperkeratosis of the squamous epithelium of the stomach was found in two homozygous females assessed at 2 weeks of age

vision/eye
N
• eye examinations of one female at 13 days of age and one male and one female at 16 days of age revealed no abnormalities

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Compton-North congenital myopathy DOID:0080101 OMIM:612540
J:222308


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory