Phenotypes Associated with This Genotype

Genotype
MGI:5523885

• Allelic Composition: Scn1a^tm2.1Kzy/Scn1a⁺; Tg(Slc32a1-cre)65Kzy/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:202863 )

• only 1 animal (1/65) lived to P35; rate is much higher than heterozygous Scn1a^tm2.2Kzy animals

postnatal lethality ( J:202863 )

• seizures occasionally result in immediate death

behavior/neurological

convulsive seizures ( J:202863 )

• mice are physically normal during first 2 weeks postnatal, but around P16 develop spontaneous generalized convulsive seizures

nervous system

convulsive seizures ( J:202863 )

• mice are physically normal during first 2 weeks postnatal, but around P16 develop spontaneous generalized convulsive seizures

abnormal postictal brain wave pattern ( J:202863 )

• in cases of lethal seizures, postictal eletrocorticography (ECoG) activity progressively decreases and is undetectable within one minute after the seizure ends; if activity is maintained until recovery from postictal immobility and electrocorticography suppression, death does not result