Analysis Tools
cardiovascular system
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• with increased surface area and branching points in the retinal inner plexiform layer of mice treated with tamoxifen from P1 to P4
• in the retinal tissue between the inner plexiform layer and ganglion cell layer of mice treated with tamoxifen from P1 to P4
• in the retinal inner and outer plexiform layer, lung, heart, brain, kidney, liver and cornea of mice treated with tamoxifen as adults
• after left anterior descending coronary artery ligation in tamoxifen-treated mice
• the retina of neonates treated with tamoxifen exhibit increased tip cells by P5 compared with control mice
• however, tamoxifen-treated mice exhibit normal vascular maturation and perfusion
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• 8 weeks after left anterior descending coronary artery ligation, tamoxifen-treated mice exhibit decreased infarct area and increase in PECAM-1 positive vessels in infarcted and non-infarcted areas compared with control mice
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• in tamoxifen treated mice exposed to high concentration of VEGF-A
• however, permeability is normal without VEGF-A treatment or with the addition of SU1498 (anti-VEGF-A inhibitor)
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cellular
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• in the retina (ganglion cell layer and inner and outer plexiform layer) of tamoxifen-treated mice at P21
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growth/size/body
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• at P21 in mice treated with tamoxifen as neonates
• however, mice treated with tamoxifen as adults are not visibly different from wild-type mice
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hematopoietic system
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• at P21 in the liver of tamoxifen-treated mice
• however, tamoxifen-treated mice subjected to left anterior descending coronary artery ligation exhibit normal macrophage numbers in the infarcted myocardium
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homeostasis/metabolism
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• 8 weeks after left anterior descending coronary artery ligation, tamoxifen-treated mice exhibit decreased infarct area and increase in PECAM-1 positive vessels in infarcted and non-infarcted areas compared with control mice
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immune system
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• at P21 in the liver of tamoxifen-treated mice
• however, tamoxifen-treated mice subjected to left anterior descending coronary artery ligation exhibit normal macrophage numbers in the infarcted myocardium
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