Phenotypes Associated with This Genotype

Genotype
MGI:5523436

• Allelic Composition: Clstn3^tm1.1Amcr/Clstn3^tm1.1Amcr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:201987 )

• regional reduction of SLC17A7 and global reduction in GAD2 puncta indicating a reduction in synapse density

• significant reduction of asymmetric synapse density in stratum radiatum andof symmetric synapse density in stratum pyramidale

• reduction in both excitatory and inhibitory synapse density

abnormal dentate gyrus morphology ( J:201987 )

• regional reduction of SLC17A7 and global reduction in GAD2 puncta indicating a reduction in synapse density

abnormal hippocampus pyramidal cell layer ( J:201987 )

• significant reduction of symmetric synapse density in the CA1 stratum pyramidale

abnormal hippocampus stratum radiatum morphology ( J:201987 )

• significant reduction of asymmetric synapse density in the CA1 stratum radiatum

abnormal excitatory postsynaptic potential ( J:201987 )

• significant enhancement in fEPSP responses in hippocampal slices at the higher end of the stimulation range

decreased miniature excitatory postsynaptic current frequency ( J:201987 )

• reduction in mEPSC frequency but not amplitude

decreased miniature inhibitory postsynaptic current frequency ( J:201987 )

• reduction in mIPSC frequency but not amplitude, increase in interevent interval