Phenotypes Associated with This Genotype

Genotype
MGI:5523413

• Allelic Composition: Lrrtm4^tm1Amcr/Lrrtm4^tm1Amcr
• Genetic Background: B6.129P2-Lrrtm4^tm1Amcr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:201655 )

• spine density on dentate gyrus granule cell dendrites in the outer molecular layer is significantly reduced

decreased CNS synapse formation ( J:201655 )

• decreased activity-dependent synaptic insertion of surface AMPA receptors in dentate gyrus granule cells upon chemical stimulation

• expression analysis indicates a defect in development of excitatory presynapses in the dentate gyrus

abnormal excitatory postsynaptic potential ( J:201655 )

• reduced field excitatory postsynaptic potential (fEPSP) responses in dentate gyrus molecular layer

abnormal miniature excitatory postsynaptic currents ( J:201655 )

• reduction in mEPSC frequency but not amplitude specifically on dentate gyrus granule neurons but not CA1 neurons