Phenotypes Associated with This Genotype

Genotype
MGI:5523279

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:164749 )

• patchy interstitial mononuclear infiltration is observed at day 10, but resolves by 3 weeks; no myocyte hypertrophy is observed

dilated cardiomyopathy ( J:164749 )

• mice die by 6 days post-treatment (80 mg/kg BW IP for 5 days) from severe dilated cardiomyopathy

• oral delivery of 80 mg/kg BW tamoxifen for 7 days does not result in any mortality but treated mice exhibit a significant but reversible dilated cardiomyopathy

decreased cardiac muscle contractility ( J:164749 )

• 3 days after oral tamoxifen treatment, cardiac depression peaks with fractional shortening decreasing from 61 to 27% and end-diastolic dimension increasing

• marked transient systolic and diastolic depression occurs, with full recovery observed by 3 weeks after stopping tamoxifen treatment

muscle

abnormal myocardium layer morphology ( J:164749 )

• patchy interstitial mononuclear infiltration is observed at day 10, but resolves by 3 weeks; no myocyte hypertrophy is observed

dilated cardiomyopathy ( J:164749 )

• mice die by 6 days post-treatment (80 mg/kg BW IP for 5 days) from severe dilated cardiomyopathy

• oral delivery of 80 mg/kg BW tamoxifen for 7 days does not result in any mortality but treated mice exhibit a significant but reversible dilated cardiomyopathy

decreased cardiac muscle contractility ( J:164749 )

• 3 days after oral tamoxifen treatment, cardiac depression peaks with fractional shortening decreasing from 61 to 27% and end-diastolic dimension increasing

• marked transient systolic and diastolic depression occurs, with full recovery observed by 3 weeks after stopping tamoxifen treatment