Phenotypes Associated with This Genotype

Genotype
MGI:5522965

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal female reproductive system morphology ( J:198638 )

♀ • severe anterior homeotic transformations of reproductive structures

abnormal internal female genitalia morphology ( J:198638 )

♀ • the uterotubal junction (connecting the uterus and oviduct) is poorly defined, elongated and shifter posteriorly

abnormal uterus morphology ( J:198638 )

♀ • reduction of the stromal layer and an increase in luminal branching

♀ • uteri resemble oviducts

♀ • keratinization and pseudostratification of the epithelium in the posterior uterus

abnormal endometrial gland morphology ( J:198638 )

♀ • dramatic reduction in uterine gland tissue

thin myometrium ( J:198638 )

♀

thin uterus ( J:198638 )

♀ • extremely thin along the entire length, resembling oviducts

abnormal spermatogenesis ( J:198638 )

♂ • failure of spermatogenesis due to cryptorchidism

abnormal internal male genitalia morphology ( J:198638 )

♂ • elongation of the junction between the caudal epididymis and vas deferens

bilateral cryptorchism ( J:198638 )

♂ • fully penetrant bilateral cryptorchidism

♂ • testes are located just below the inferior pole of the kidney

abnormal cauda epididymis morphology ( J:198638 )

♂ • smaller with a thinner muscle layer

♂ • resembles the more anterior caput segment

small epididymis ( J:198638 )

♂ • smaller caudal epididymis

abnormal vas deferens morphology ( J:198638 )

♂ • partial anterior homeotic transformation towards an epididymis

♂ • posterior shifting and coiling of the vas deferens near the epididymal junction

♂ • dramatically reduced muscle and stromal layers

female infertility ( J:198638 )

♀

male infertility ( J:198638 )

♂

endocrine/exocrine glands

abnormal endometrial gland morphology ( J:198638 )

♀ • dramatic reduction in uterine gland tissue

bilateral cryptorchism ( J:198638 )

♂ • fully penetrant bilateral cryptorchidism

♂ • testes are located just below the inferior pole of the kidney