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Phenotypes Associated with This Genotype
Genotype
MGI:5522833
Allelic
Composition
Tubb2bbrdp/Tubb2bbrdp
Genetic
Background
involves: A/J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb2bbrdp mutation (0 available); any Tubb2b mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive birth

respiratory system
• some mice are gasping at P0

nervous system
• slightly in the cortex and striatum at E14.5
• in the cortex and striatum at E16.5
• at E18.5
• increased at E14.5
• modest in the ventricular zone and more so away from the ventricular zone
• reduced striatal axons leading to and forming the internal capsule
• reduced at E11.5 (slightly), E14.5 (increasing severity in the caudal portion), E16.5 (more severe in the posterior region) and E18.5
• reduced neuroepithelium thickness in the caudolateral telencephalon at E18.5
• wave-like perturbation in the cerebral cortex at E18.5
• hypoplastic, irregular ventricular zone at E18.5
• at E16.5 (more severe in the posterior region) and E18.5
• at E18.5

craniofacial
• slightly at E18.5

cellular
• slightly in the cortex and striatum at E14.5
• in the cortex and striatum at E16.5
• at E18.5
• increased at E14.5
• modest in the ventricular zone and more so away from the ventricular zone

growth/size/body
• slightly at E18.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory