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Phenotypes Associated with This Genotype
Genotype
MGI:5522716
Allelic
Composition		 TigarGt(EUCE0047g05)Hmgu/TigarGt(EUCE0047g05)Hmgu
Apctm1Tno/Apctm1Tno
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (5 available); any Apc mutation (156 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
TigarGt(EUCE0047g05)Hmgu mutation (0 available); any Tigar mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:198650 )
• in tamoxifen-treated mice compared with Apctm1Tno/Apctm1Tno Lgr5tm1(cre/ERT2)Cle/Lgr5+ mice

neoplasm
decreased tumor growth/size ( J:198650 )
• tamoxifen-treated mice exhibit a reduced total tumor burden and average tumor size of abnormally proliferating adenomas in the small intestine and reduced size, but not number, of colon adenomas due to reduced proliferation and increased reactive oxygen species damage compared with Apctm1Tno/Apctm1Tno Lgr5tm1(cre/ERT2)Cle/Lgr5+ mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory