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Phenotypes Associated with This Genotype
Genotype
MGI:5521585
Allelic
Composition
Apctm2Tno/Apc+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Tno mutation (0 available); any Apc mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• treatment with pioglitazone or bezafibrate suppresses polyp development

homeostasis/metabolism
• total cholesterol levels are increased between 6 and 12 weeks of age
• free fatty acid levels are increased at 12 weeks of age
• triglyceride levels are increased after 6 weeks of age, with levels almost 10 times higher at 12 weeks of age than at 6 weeks of age
• seen with age
• treatment with pioglitazone or bezafibrate decreases serum lipid levels and reduces severity of hepatic steatosis

liver/biliary system
• centrilobular-restricted steatosis is seen in the livers of all mutants at 12 weeks of age, with numerous microvesicular fatty droplets in the cytoplasm of parenchymal cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial adenomatous polyposis DOID:0050424 OMIM:PS175100
J:86036


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory