Phenotypes Associated with This Genotype

Genotype
MGI:5521559

• Allelic Composition: Gt(ROSA)26Sor^{tm4(H1/tetO-RNAi:Ezh2)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:202724 )

• no mice are recovered at birth when exposed to doxycycline throughout pregnancy

integument

abnormal mammary gland development ( J:202724 )

• mice treated with doxycycline from birth exhibit a net loss of luminal cells coupled with enhanced differentiation to maintain the pool of differentiated luminal cells compared with wild-type mice

endocrine/exocrine glands

abnormal mammary gland development ( J:202724 )

• mice treated with doxycycline from birth exhibit a net loss of luminal cells coupled with enhanced differentiation to maintain the pool of differentiated luminal cells compared with wild-type mice