Phenotypes Associated with This Genotype

Genotype
MGI:5521506

• Allelic Composition: Mirc19^tm1.2Arte/Mirc19^tm1.2Arte
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:200865 )

N • mice are fertile

nervous system

nervous system phenotype ( J:200865 )

N • mice exhibit normal paired-pulse facilitation

abnormal dendrite morphology ( J:200865 )

• reduced dendrite length and branch points in cortical cultures after 24 but not 48, 72 or 96 hours

abnormal excitatory postsynaptic potential ( J:200865 )

• smaller field excitatory postsynaptic potential

enhanced long-term potentiation ( J:200865 )

• when induced by theta burst stimulation

• however, long term potentiation induced tetanic stimulation is normal

abnormal miniature excitatory postsynaptic currents ( J:200865 )

• reduced average amplitude and quantal size of glutamatergic miniature excitatory postsynaptic currents

immune system

immune system phenotype ( J:200865 )

N • bone marrow-derived macrophages exhibit normal cytokine response to LPS treatment