Phenotypes Associated with This Genotype

Genotype
MGI:5521480

• Allelic Composition: Fcgr4^tm1Rav/Fcgr4^tm1Rav; Tg(Ctsk-cre)1Rda/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:197378 )

N • normal osteoclastogenesis in the presence of FCGR4 cross-linking antibodies

decreased osteoclast cell number ( J:197378 )

autoimmune arthritis ( J:197378 )

• no reduction in clinical signs of arthritis in the presence of FCGR4 cross-linking antibodies

decreased bone resorption ( J:197378 )

• reduced bone erosion in the presence of FCGR4 cross-linking antibodies

homeostasis/metabolism

abnormal circulating protein level ( J:197378 )

• reduced serum collagen 1 fragments in the presence of FCGR4 cross-linking antibodies

immune system

decreased osteoclast cell number ( J:197378 )

autoimmune arthritis ( J:197378 )

• no reduction in clinical signs of arthritis in the presence of FCGR4 cross-linking antibodies

hematopoietic system

decreased osteoclast cell number ( J:197378 )