Phenotypes Associated with This Genotype

Genotype
MGI:5521287

• Allelic Composition: Tg(Thy1-MAPT)22Schd/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:197067 )

• 12 month old mutants exhibit increased agitation in home cage activity during the initial exploration/introduction phase

increased aggression towards mice ( J:197067 )

• in the tube test of aggression and dominance, 12 month old mutants repeatedly push the opponent mouse out of the tube, resulting in more wins and indicating increased aggression

anhedonia ( J:197067 )

• food-rewarded operant conditioning nosepokes are lower in 12 month old mutants than wild-type mice in variable interval trials

behavioral despair ( J:197067 )

• in the tail suspension test, 12 month old mutants struggle less vigorously and show longer times of total immobility, indicating increased depression-like behaviors

abnormal locomotor circadian rhythm ( J:197067 )

• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle

hyperactivity ( J:197067 )

• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle

homeostasis/metabolism

decreased serotonin level ( J:197067 )

• hippocampal 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels are lower in 12 month old mutants than in wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:197067