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Phenotypes Associated with This Genotype
Genotype
MGI:5521287
Allelic
Composition
Tg(Thy1-MAPT)22Schd/0
Genetic
Background
involves: C57BL/6 * CBA
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phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle
• 12 month old mutants exhibit increased agitation in home cage activity during the initial exploration/introduction phase
• in the tube test of aggression and dominance, 12 month old mutants repeatedly push the opponent mouse out of the tube, resulting in more wins and indicating increased aggression
• food-rewarded operant conditioning nosepokes are lower in 12 month old mutants than wild-type mice in variable interval trials
• in the tail suspension test, 12 month old mutants struggle less vigorously and show longer times of total immobility, indicating increased depression-like behaviors
• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle

homeostasis/metabolism
• hippocampal 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels are lower in 12 month old mutants than in wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:197067


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory