Mouse Genome Informatics
tg
    Tg(Thy1-MAPT)22Schd/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle
• in the tube test of aggression and dominance, 12 month old mutants repeatedly push the opponent mouse out of the tube, resulting in more wins and indicating increased aggression
• food-rewarded operant conditioning nosepokes are lower in 12 month old mutants than wild-type mice in variable interval trials
• in the tail suspension test, 12 month old mutants struggle less vigorously and show longer times of total immobility, indicating increased depression-like behaviors
• 12 month old mutants exhibit increased agitation in home cage activity during the initial exploration/introduction phase
• 12 month old mutants exhibit hyperactivity during the dark phase of the cycle

homeostasis/metabolism
• hippocampal 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels are lower in 12 month old mutants than in wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:197067