Phenotypes Associated with This Genotype

Genotype
MGI:5520959

• Allelic Composition: Prss37^tm1Zgwg/Prss37^tm1Zgwg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:202066 , J:202066 )

♀N • female mice are fertile (J:202066)

♂N • male mice exhibit normal spermatogenesis, sperm morphology and motility and capacitation (J:202066)

impaired sperm migration in female genital tract ( J:202066 )

♂ • impaired sperm migration from the uterus into the oviduct

male infertility ( J:202066 )

♂

impaired fertilization ( J:202066 )

♂ • severely impaired fertilization in vivo (2.3% vs. 70% of that in control mice)

♂ • however, sperm are able to fertilize cumulus-intact oocytes in vitro

impaired binding of sperm to zona pellucida ( J:202066 )

♂ • in vitro, sperm are unable to bind zona-intact oocytes

cellular

impaired sperm migration in female genital tract ( J:202066 )

♂ • impaired sperm migration from the uterus into the oviduct