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Phenotypes Associated with This Genotype
Genotype
MGI:5520919
Allelic
Composition
Ticam1Lps2/Ticam1Lps2
Genetic
Background
C57BL/6J-Ticam1Lps2/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• rMA15-SARS-CoV-infected mice show increased recruitment of neutrophils in the lungs at 4 dpi, however by 6 dpi, this is no longer different
• mice show more plasmacytoid dendritic cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences from wild-type are seen in populations of eosinophils, monocyte-derived dendritic cells or in CD11b+ dendritic cell populations, or lymphocytes after rMA15-SARS-CoV infection
• mice show fewer CD8+ T cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences in the number of CD4+ T cells are seen
• mice show more alveolar macrophages in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• mice show more Ly6C high inflammatory monocytes following rMA15-SARS-CoV infection at 4 dpi but not on 6 dpi
• mice show similar numbers of Ly6C low monocytes as wild-type mice following rMA15-SARS-CoV infection at 4 dpi but lower numbers at 6 dpi
• levels of chemokines that are chemotactic for neutrophil recruitment (CXCL1, CXCL2, CXCL3) are lower on 2 dpi with rMA15-SARS-CoV but are higher on 4 dpi
• rMA15-SARS-CoV-infected mice show increased IFN-beta levels in lung homogenates on 2 and 4 dpi
• mice infected intranasally with the mouse-adapted rMA15-SARS-CoV show greater weight loss and continue to lose weight when wild-type mice are recovering, increased viral loads in the lungs and detectable virus at day 6 post-infection when wild-type mice clear the virus
• mice show greater susceptibility to SARS-CoV infection than Tlr3tm1Flv homozygotes
• rMA15-SARS-CoV-infected mice show more viral antigen in the lungs; more viral antigen is seen in the parenchyma of the lungs but not in the large airways when compared to wild-type mice
• in the large airways, infected cells in the large airways are ciliated airway epithelial cells and are type II pneumocytes in the alveolar spaces

mortality/aging

homeostasis/metabolism
• levels of chemokines that are chemotactic for neutrophil recruitment (CXCL1, CXCL2, CXCL3) are lower on 2 dpi with rMA15-SARS-CoV but are higher on 4 dpi
• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa compared with wild-type mice

respiratory system
• rMA15-SARS-CoV-infected mice show severe hemorrhage in the lungs at day 6 post-infection
• rMA15-SARS-CoV-infected mice show higher levels of enhanced and infection-associated airway obstruction
• rMA15-SARS-CoV-infected mice show higher levels of enhanced pause indicating airway hyperresponsiveness
• rMA15-SARS-CoV-infected mice show higher midtidal expiratory flow

cardiovascular system
• rMA15-SARS-CoV-infected mice show severe hemorrhage in the lungs at day 6 post-infection

hematopoietic system
• rMA15-SARS-CoV-infected mice show increased recruitment of neutrophils in the lungs at 4 dpi, however by 6 dpi, this is no longer different
• mice show more plasmacytoid dendritic cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences from wild-type are seen in populations of eosinophils, monocyte-derived dendritic cells or in CD11b+ dendritic cell populations, or lymphocytes after rMA15-SARS-CoV infection
• mice show fewer CD8+ T cells in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• however, no differences in the number of CD4+ T cells are seen
• mice show more alveolar macrophages in the lungs at 6 dpi, but not 4 dpi, with rMA15-SARS-CoV
• mice show more Ly6C high inflammatory monocytes following rMA15-SARS-CoV infection at 4 dpi but not on 6 dpi
• mice show similar numbers of Ly6C low monocytes as wild-type mice following rMA15-SARS-CoV infection at 4 dpi but lower numbers at 6 dpi


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory